Cut bread into 1 inch thick slices. Arrange bread slices and pecans on a baking sheet and drizzle with melted butter; toast lightly.
In a large bowl, beat together eggs, cream, milk, cinnamon, nutmeg, sugar and vanilla. Put bread and pecans in a lightly greased 7x11 in casserole dish.
Pour egg mixture over bread. Make sure that bread slices are saturated with liquid.
Bake in preheated oven for 60 minutes, until golden.