Preheat oven to 400F. Line a baking sheet with foil and mist with cooking spray. Mash bread together with milk in a large bowl until smooth.
Add turkey, Parmesan, parsley, eggs, salt, onion and garlic powders, oregano and 2 Tbsp. ketchup to bowl; mix well. Form into a 9-by-5-inch loaf on baking sheet.
Spread remaining ketchup on top.
Bake until an instant-read thermometer inserted into center of meat loaf registers 165F, 45 to 50 minutes. Turn broiler to high and broil meat loaf to crisp exterior, 1 to 3 minutes.