Cut bread into quarters; cut quarters in half horizontally.
Place bread quarters, cut sides up, on a baking sheet. Top each bread bottom with 2 meatloaf slices, 2 Tbsp. marinara sauce, and 1/4 cup cheese. Top each bread top with 2 Tbsp. marinara sauce and 1/4 cup cheese; sprinkle evenly with Italian seasoning.
Bake at 375 for 10 to 15 minutes or until cheese melts and meat is thoroughly heated. Top bread bottoms with bread tops, and serve sandwiches immediately.
