Combine cream cheese, horseradish, and mustard; stir until smooth. Cover and chill.
Combine wine and butter in a large heavy-duty zip-top plastic bag; add roast. Seal and chill at least 8 hours or up to 24 hours, turning occasionally.
Preheat oven to 50
Remove roast from marinade, discarding marinade.
Place roast in a 13 x 9-inch pan lined with heavy-duty foil.
Combine salt and pepper, and rub over surface of roast.
Bake, uncovered, at 500 for 20 to 30 minutes. Turn oven off. Do not open oven door for 2 hours. Meat thermometer should register 145 (medium-rare) to 160 (medium). Thinly slice meat, reserving pan juices.