Place granulated sugar and butter in a large bowl; beat with a mixer at medium speed until well blended (about 3 minutes).
Add egg substitute; beat 3 minutes. Beat in sour cream, water, and vanilla.
Lightly spoon flour into dry measuring cups; level with a knife.
Combine flour, baking powder, baking soda, and salt in a large bowl, stirring well with a whisk. Make a well in center of mixture; add sour cream mixture. Stir just until combined.
Place 3 tablespoons brown sugar mixture in a small bowl; set aside.
Sprinkle surface of batter with remaining brown sugar mixture. Gently fold batter 4 times.
Place 18 paper muffin cup liners in muffin cups; coat liners with cooking spray. Spoon batter into prepared cups.
Sprinkle batter evenly with reserved brown sugar mixture.
Bake at 400 for 25 minutes or until a wooden pick inserted in center comes out clean.
Remove muffins from pan immediately; place on a wire rack. Cool 10 minutes.
Combine powdered sugar, juice, and dash of salt in a small bowl, stirring until smooth.
Drizzle powdered sugar mixture evenly over muffins.